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| Outlines/Features of Research |
We developed a new "host-guest gel", whose stiffness can reversibly be switched by dissolving competing host/guest molecules in solutions. It enables us to recapitulate dynamic changes in extracellular microenviroments. We demonstrated the morphological swithcing of somatic cells and the maintenance of human/mouse stem cell functions on our hydrogels over a month.
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| Differences with Conventional/Competitive Technologies |
In contrast to chemically cross-linked polymer substrates, "dynamic" substrates enabling the reversible switching of stiffness open a large potential to study how cells respond to mechanical "stresses".
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| Expected Applications |
The petri dishes and cell culture flasks whose bottom surfaces are coated with our dynamic polymer substrates can be apllied as (1) the basic research in cell biology and mechanobiology, (2) quality control of cell products for basic research as well as for regenerative medicine.
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| Profile Institution URL |
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1995-1998 PhD, Department of Molecular Engineering,Kyoto University
1998-2001 PostDoc, Department of Physics,Technical University Munich 2001-2005 Independent Group Leader (Emmy Noether Fellow), Department of Physics, Technical University Munich 2005- Professor, Physical Chemistry of Biosystems, Institute of Physical Chemistry, Heidelberg University 2007- Faculty (joint appointment), Faculty of Physics and Astronomy, Heidelberg University 2007- Faculty, The Hartmut Hoffmann-Berling, International Graduate School of Molecular and Cellular Biology, Heidelberg University 2013-2017 Professor (HeKKSaGOn professorship), Institute for Integrated Cell-Material Sciences, Kyoto University 2017-2018 Visiting Professor, Institute for Integrated Cell-Material Sciences, Kyoto University 2018- Professor, Center for Integrative Medicine and Physics (CiMPhy), Institute for Advanced Study, Kyoto University |
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